School of Medicine

Wayne State University School of Medicine

Objectives

1. To elucidate the environmental, psychosocial, biological, and genetic factors, as well as their interactions, and the mediators of their effects, on physiological responses.

Hypothesis: Psychosocial factors will independently impact as well as interact with biological and genetic factors to explain a significant proportion of the variation in physiological responses to interventions undertaken.

2. To better understand the relationship of environmental exposures, socioeconomic status and psychosocial factors to biological, and genetic characteristics of free-living African Americans.

Hypothesis: Environmental and psychosocial factors will correlate differentially with biological and genetic factors, and better understanding of these relationships will facilitate development of interventions to favorably affect modifiable factors.

3. To understand the contribution of environmental, social support, and individual characteristics that predict the success or failure of multi-faceted interventions that promote adoption of healthy lifestyles.

Hypothesis: Environmental and individual attributes will impact the adoption of multi-faceted lifestyle interventions.

4. To determine whether patients with advanced cardiovascular disease are more likely to adopt healthy lifestyles, and improve both physiological measures and disease-specific process of care measures, when counseling is provided to dyads versus counseling only of the affected patient.

Hypothesis: Counseling of dyads will prove more effective than solely counseling individual patients affected with advanced cardiovascular disease.

5. To develop a multi-disciplinary research infrastructure to effectively integrate established investigators as well as to identify and mentor junior investigators by providing shared research support consisting of essential research services and equipment, cognitive expertise, and a sense of common purpose for the pursuit of multi-level research into racial/ethnic health disparities.